Breaking tolerance to pancreatic cancer unresponsiveness to chemotherapy

Pancreatic cancer is increasingly diagnosed around the world. Due to its late presentation, the disease remains incurable for the most part. Chemotherapy and adjunct therapies including palliative biliary stenting or bypass, along with pain management, are the main methods of treatment but which do not prolong life. This book is part of an ongoing series, ‘Cancer sensitizing agents for chemotherapy’, which seeks to advance the field by summarizing current knowledge of pancreatic cancer biology and the targets for chemotherapies. The book is divided in 11 chapters where, the current concepts of chemoresistance in the pancreas, some of the possible therapeutic targets and newer molecules for therapy are discussed. One chapter in the book is dedicated to pancreatic cancer trails and issues in it, which is important. Newer targets such as the epigenome and the use of nanocarriers and small molecules are discussed. Molecular markers for treatment response are listed in a comprehensive manner. The utility of this book is that it is timely, and all this information is brought together in one slim volume. This book should be useful for cancer researchers, in general, and should be indispensable in the library of the researcher on pancreatic cancer.