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Authors’ response
161 (
4
); 428-429
doi:
10.25259/IJMR_1307_2025

Authors’ response

1Department of Endocrinology, Sher-I-Kashmir Institute of Medical, Sciences, Srinagar, 190 011, Jammu & Kashmir, India
2Department of Immunology & Molecular Medicine, Sher-I-Kashmir Institute of Medical, Sciences, Srinagar, 190 011, Jammu & Kashmir, India
3Department of Cardiology, Sher-I-Kashmir Institute of Medical, Sciences, Srinagar, 190 011, Jammu & Kashmir, India

*For correspondence: drlaway@gmail.com

Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

Sir,

We greatly appreciate the reader’s interest in our article1 published in the June 2024 issue of Indian Journal of Medical Research, which has raised intriguing questions.

As rightly pointed by the author that the aforementioned study has a small sample size, and its conclusions may not be generalizable2. This represented our attempt to study pituitary functions within this cohort of patients, and we hope that larger studies will be conducted in the future.

Regarding confounding factors, we excluded all chronic diseases and conditions, including drug intake that could have interfered with the assessment of pituitary hormones. Furthermore, the patients were monitored and reassessed, which plausibly minimized the impact of acute stress on pituitary hormones.

As mentioned in the introduction of the article, we hypothesized that hypoperfusion due to a complete heart block could lead to vasospasm and hypoxia of pituitary tissue, resulting in long-term pituitary dysfunction3.

We once again thank the reader for their insightful comments and the opportunity to elaborate on our study.

Financial support & sponsorship

None.

Conflicts of Interest

None.

Use of Artificial Intelligence (AI)-Assisted Technology for manuscript preparation

The authors confirm that there was no use of AI-assisted technology for assisting in the writing of the manuscript and no images were manipulated using AI.

References

  1. , , , , , , et al. Anterior pituitary hormone dysfunction among individuals with complete heart block requiring pacemaker. Indian J Med Res. 2024;159:695-701.
    [Google Scholar]
  2. . Pituitary dysfunction in heart block: The need for broader insight. Indian J Med Res. 2025;161:428.
    [Google Scholar]
  3. , , , . The central nervous system cytokine response to global ischemia following resuscitation from ventricular fibrillation in a porcine model. Resuscitation. 2009;80:249-52.
    [Google Scholar]
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