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Health related quality of life in patients with type I diabetes mellitus: generic & disease-specific measurement
Reprint requests: Dr H.E. Hart, Institute for Health Policy & Management, Erasmus University Rotterdam c/o Erasmuslaan 68 3707 ZE Zeist, The Netherlands e-mail: Bertien.Hart@planet.nl
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Received: ,
Abstract
Background & objectives:
An ideal instrument for the assessment of health related quality of life (HRQOL) in patients with diabetes mellitus type I (T1DM) should incorporate the benefits of both generic and disease-specific instruments. The objective of this study was to investigate the responsiveness and the ability to provide information about diabetes-specific associations with HRQOL, of two generic instruments, in comparison with two diabetes-specific instruments, in patients with T1DM.
Methods:
In a Dutch cohort of 234 patients with T1DM we longitudinally assessed HRQOL using both generic and diabetes-specific instruments. We investigated the responsiveness, the associations with diabetes-specific variables and the identification of specific patients by the instruments used.
Results:
The generic RAND-36 was able to detect statistically significant and clinically relevant changes in HRQOL over time. Moreover, the RAND-36 was associated with (changes in) diabetesspecific variables. The generic and diabetes-specific instruments partly identified different patients with lowest HRQOL.
Interpretation & conclusion:
The RAND-36 was highly responsive to changes in HRQOL in patients with T1DM and revealed diabetes-specific associations with HRQOL. A low correlation between the generic and diabetes-specific instruments and partly different identification of patients with lower HRQOL support the complementary use of these instruments in patients with T1DM.
