Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research Indan Journal of Medical Research
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REVIEW ARTICLE
Year : 2013  |  Volume : 138  |  Issue : 1  |  Page : 60-67

Biomarkers for the management of pre-eclampsia in pregnant women


1 Molecular Diagnostics & Biomarkers Laboratory, Global Hospitals, Hyderabad, India
2 Department of Academics & Research, Global Hospitals, Hyderabad, India
3 Durgabai Deshmukh Hospital & Research Centre, Molecular Genetics Laboratory, Vasavi Medical & Research Centre, Hyderabad, India

Correspondence Address:
V Sritharan
Consultant & Head, Molecular Diagnostics & Biomarkers Laboratory, Global Hospitals, 6-1-1-70/1-4, Lakdi-ka-pool, Hyderabad 500 004
India
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Source of Support: None, Conflict of Interest: None


PMID: 24056556

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Pre-eclampsia (PE) is a pregnancy related disorder characterized by hypertension and proteinuria noticeable after 20 wk of gestation. It is a leading cause of maternal and foetal mortality and morbidity worldwide. The aetiology of the disease is unknown, but recent studies have revealed that this disorder appears to originate in placenta and is characterized by widespread maternal endothelial dysfunction. Till date, delivery of placenta is the only cure for the disease. So, there is a need for the identification of highly specific and sensitive biochemical markers that would allow early identification of patients at risk and thus help in providing proper prenatal care. Several promising biomarkers have been proposed, alone or in combination, that may help in predicting women who are likely to develop PE. Maternal serum concentrations of these biomarkers either increase or decrease in PE during gestation. This review focuses on the various biomarkers available and their utility in predicting pre-eclampsia.


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